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Journal of Child Health Care, Vol. 10, No. 4, 337-350 (2006)
DOI: 10.1177/1367493506067886

Retention of survivors of acute lymphoblastic leukemia in a longitudinal study of bone mineral density

Deborah B. Crom, RN, PhD

Department of Hematology-Oncology, St Jude Children's Research Hospital; Department of Nursing, University of Tennessee Health Science Center, Memphis, TN, USA

Vida L. Tyc, PhD

St Jude Children's Research Hospital, Memphis, TN, USA

Shesh N. Rai, PhD

Department of Biostatistics, St Jude Children's Research Hospital, Memphis, TN, USA

X. Deng, MS

Department of Biostatistics, St Jude Children's Research Hospital, Memphis, TN, USA

Melissa M. Hudson, MD

Department of Hematology-Oncology, St Jude Children's Research Hospital and Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN, USA

Andrea Booth, BA

Division of Behavioral Medicine, St Jude Children's Research Hospital, Memphis, TN, USA

Leslie N. Rodrigues, MS

Department of Behavioral Medicine, St Jude Children's Research Hospital, Memphis, TN, USA

L. Zhang, MS

Department of Biostatistics, St Jude Children's Research Hospital, Memphis, TN, USA

Elizabeth Mccammon, BSN

Department of Radiological Sciences (Division of Diagnostic Imaging), St Jude Children's Research Hospital, Memphis, TN, USA

Sue C. Kaste, DO

Department of Radiological Sciences (Division of Diagnostic Imaging), St Jude Children's Research Hospital and Department of Radiology, University of Tennessee Health Science Center, Memphis, TN, USA

Attrition in longitudinal studies of survivors of childhood cancer reduces these studies’ statistical power, introduces bias and threatens internal and external validity. This study investigated the variables associated with dropout of survivors of acute lymphoblastic leukemia in a trial investigating the effect of vitamin D and calcium supplementation and nutritional counseling on bone mineral density (BMD). Twenty-five participants withdrew from the study. Common reasons given for withdrawing were intolerance of the study drug, family hardship and schedule conflicts. Few statistically and clinically significant differences identified participants who completed the study. Nurses need to be aware of the reasons that participants withdraw from clinical trials, as they are in a strategic position to encourage patients to participate in health promotion studies.

Key Words: attrition • childhood cancer survivors • participant retention


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